Beilstein J. Org. Chem.2014,10, 2756–2764, doi:10.3762/bjoc.10.292
such as polyethylene glycol (PEG). On the other hand, PEGylated liposomes have been utilized as a representative anticancer drug carrier. However, little is known about the formation of CD PPRX with PEGylatedliposome. In the present study, we first report the formation of CD PPRX with PEGylated
liposome and evaluate it as a sustained release drug carrier. PEGylatedliposome encapsulating doxorubicin was disrupted by the addition of α-CD. Meanwhile, γ-CD included two PEG chains and/or one bending PEG chain of PEGylatedliposome and formed PPRX without the disruption of the membrane integrity of
the PEGylatedliposome. Moreover, the release of doxorubicin and/or PEGylatedliposome encapsulating doxorubicin from the PPRX was prolonged in accordance with the matrix type release mechanism. These findings suggest the potential of γ-CD PPRX as sustained release carriers for PEGylatedliposome
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Graphical Abstract
Figure 1:
(A) Photographs and (B) powder X-ray diffraction patterns of precipitates formed by mixing the CD s...